Nutrition & Supplements

Even if we understand that MINPP1's defect will impact only some specific cells in specific organs (cerebellum, brainstem, pons, eye, ...), we can still moderate its levels in the whole body. Food and Supplements to modulate MINPP1's defect:

1. High Phytic Acid levels:

A. A nutritional approach to reduce food sources of phytic acid. We recommend exploring this article because it explicitly advises on achieving this purpose: https://www.soulfoodshonali.com/blog/what-is-phytic-acid-and-why-neutralize-it-in-grains-and-beans/

B. Provide specific nutraceuticals in the form of supplements to achieve two objectives:

  • Degrade excess phytic acid by adding the enzyme involved in this process: phytase
  • Adding substances capable of preventing the "sequestration" of salts such as calcium, iron, magnesium. In this sense, Vitamin C appears strong enough to overcome phytic acid. In one study, adding 50 mg of vitamin C counteracted the phytic acid load of a meal.

2. Chelation: 

Daily intake of Calcium, Iron and Magnesium which are broken down by excess of phytic acid. 

In any case Vitamin D & Calcium are also keys to support bone metabolism. Due to lack of walking and hypotonia, MINPP1 kids may tend to have less bone density. In addition, some seizure control medicines affects Vitamin D assimilation in the body. Consequently, taking both Vitamin D and Calcium daily is critical. 

3. Reduce cellular death by apoptosis deregulation: 

Food to protect cells from oxidative stress:

  • Vitamin C: citric fruits (maximum 1/week) and some vegetables such as pepper, tomato, green leafy vegetables and parsley
  • Vitamin E: seeds (flax, sesame, chia, etc.) and vegetable oils (notably extra virgin olive oil), avocado
  • Vitamin A: carrot, broccoli, sweet potato, cabbage, spinach, melon, apricot, mango, egg, dairy product, veal, chicken, turkey, blue fish
  • Carotene: tomato, carrot, lettuce, asparagus, broccoli, squash, cabbage, seaweed
  • Lutein Cruciferous: cabbage, Brussels sprouts, cauliflower and broccoli
  • Polyphenols: blueberries, blackberries, cherries, strawberries, raspberries, grapes, citrus (control), green tea, matcha tea, nuts, turmeric (control) and cocoa
  • Glutathione: asparagus, broccoli, garlic, cabbage, onions, sauerkraut (control), Brussels sprouts, cumin, cinnamon. In smaller quantities melon, avocado, grapefruit, orange, nuts, turkey and chicken
  • Selenium: brazil nut
  • Magnesium: bananas, plums, melons, grapes, apricots, raspberries, pears, pineapple, orange, dates, papayas, peaches, walnuts, almonds, hazelnuts, peanuts, chestnuts, pistachios, pine nuts, chickpeas, peas, white beans, spinach, lettuce, borage, asparagus, cucumber, radish, celery, endive, corn, brown rice, wholewheat bread, oat flour (s/gluten), snails, cocoa, chocolate
  • Zinc: egg yolk, white beans, lentils, sardines, celery, asparagus, borage, eggplant, figs, peaches and potatoes
  • B vitamins, such as B6, B9 (folate), and B12, are involved in various cellular processes and indirectly support cell survival. 

4. Promote neurogenesis:

Omega 3, 6 and 9:

  • Blue fish: (1 time per week) anchovies, sardines, herring, salmon, trout
  • Semi-fatty fish (DHA is in smaller quantities): gilthead sea bream, turbot, sea bass
  • Avocado: 1-2 per week
  • Nuts: almond, hazelnuts, walnuts, brazil nuts, ....
  • Seeds: (crushed) flaxseeds, chia, pumpkins, sesame (not sunflower)
  • Extra virgin olive oil: daily 
  • Phosphatidyl Choline (PC) supplement 

Like any human being, the less sugar the better. Its inflammatory effects are promoting epilepsy. 

 As a rule of thumb, giving a balanced multivitamin daily is a must to help the body to thrive. Considering an adapted probiotic intake is good since it promotes good digestion and immune system.